Segmentation is one of several analytical techniques that can be used to understand how disease and morbidity are distributed within a population. Slough Clinical Commissioning Group (CCG), which covers a population of 143,000 in the UK, used the Johns Hopkins ACG System to conduct a population health analysis that generated several new insights. After just 18 months, unplanned hospitalizations were reduced by 18% and emergency department visits were reduced by 19%.